Study of the D-dimer, C-reactive protein, and autoantibodies markers among HBV infected patients in Babylon province, Iraq

Ahmed Abdul-Abbas BayramFollow
Hussein O.M. Al-Dahmoshi, College of science, University of Babylon, Babylon, Hilla City, IraqFollow
Noor S.K. Al-Khafaji, College of science, University of Babylon, Babylon, Hilla City, IraqFollow
Raheem Tuama Obayes Al Mammori, Babylon GIT Center, Babylon, Hilla City, IraqFollow
Ali Husain Shilib Al-Shimmery, Babylon GIT Center, Babylon, Hilla City, IraqFollow
Morteza Saki, ahvaz jundishapur university of medical sciencesFollow

Abstract

Background: Hepatitis B can be defined as one of the dangerous diseases caused by the hepatitis B virus (HBV), which infects the liver and causes liver failure, cirrhosis, and death.

Aims: This study aimed to evaluate the D-dimer, C-reactive protein (CRP), and autoantibodies markers among HBV- infected patients in Babylon province, Iraq, compared to a healthy control group.

Methods: In this cross-sectional study, all patients referred to GIT and liver centers in Merjan Medical City, Babylon, Iraq from January 2016 to January 2018 were screened for HBV infection by quantitative real-time polymerase chain reaction (qPCR). Antinuclear antibody (ANA), dsDNA, D-dimer, and CRP markers were examined using fluorescence technique in randomly selected patients and some healthy individuals as control group. Statistical analysis was performed using SPSS program.

Results: In this study, 424 HBV patients from different areas of Babylon province, Iraq were enrolled. A total of 40 patients and 15 healthy participants were selected for evaluation of D-dimer, CRP, ANA, and dsDNA levels. The results of the distribution of HBV-infected patient by gender per area revealed that males accounted for a higher percentage than females in all parts of Babylon provinces. Also, a highly significant increase in serum levels was observed in the patients compared to the control subjects for all the studied parameters D-dimer, ANA, dsDNA, and CRP. Overall, 5.5 % of HBV patients (3/40) had a positive ANA titer. None of the HBV patients had a positive dsDNA titer.

Conclusion: This study showed that, HBV-infected patients had elevated levels of D-dimer and CRP compared to the control group. Also, the seropositivity titers of ANA and anti-dsDNA autoantibodies were low in Iraqi HBV patients.

Recommended Citation

Bayram, Ahmed Abdul-Abbas; Al-Dahmoshi, Hussein O.M.; Al-Khafaji, Noor S.K.; Al Mammori, Raheem Tuama Obayes; Al-Shimmery, Ali Husain Shilib; and Saki, Morteza (2021) "Study of the D-dimer, C-reactive protein, and autoantibodies markers among HBV infected patients in Babylon province, Iraq," BioMedicine: Vol. 11 : Iss. 4 , Article 8.
DOI: 10.37796/2211-8039.1186