Abstract
Background: Altered acetyl CoA acetyltransferase 1 (ACAT1) expression has been reported in diverse cancers. However, the expression of ACAT1 and its prognostic value in oral squamous cell carcinoma (OSCC) has remained unexplored. Materials and methods: In this study, the expression of ACAT1 was analysed by immunohistochemistry (IHC) in 61 OSCC patients and compared between OSCC and adjacent pre-tumour tissue of 21 patients. Results: The expression of ACAT1 in OSCC tumours is heterogeneous between patients. More specifically, 52.38% of the patients show low expression of ACAT1 in both tumour and adjacent pre-tumour tissues, 9.52% of the patients show high expression of ACAT1 in both tumour and adjacent pre-tumour, 19.05% of the patients have high expression of ACAT1 in tumour tissue and low expression of ACAT1 in adjacent pre-tumour tissue and another 19.05% of the patients have low expression of ACAT1 in tumour tissue and high expression of ACAT1 in adjacent pre-tumour tissue. Conclusion: Comparison of ACAT1 expression, one of the key enzymes in the ketone body metabolic pathway, divided OSCC patients into two groups: 1) similar expression and 2) different expression of ACAT1 in tumour and adjacent pre-tumour tissue. No significant association between ACAT1 levels and overall survival was observed.
Recommended Citation
Firouzpour, Hadis; Shokrolahi, Seyed Mohammad; Bourova-Flin, Ekaterina; Derakhshan, Samira; Shahsavari, Zahra; Karimi, Abbas; Mir Mohammad Sadeghi, Hassan; and Goudarzi, Afsaneh
(2022)
"The expression of ACAT1 in oral squamous cell carcinoma and the adjacent pre-tumour tissue,"
BioMedicine: Vol. 12
:
Iss.
4
, Article 6.
DOI: 10.37796/2211-8039.1363
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