Mutation Patterns of Integrase Gene Affect Antiretroviral Resistance in Various non-B Subtypes of Human Immunodeficiency Virus Type-1 and Their Implications for Patients’ Therapy

Fauzia Andrini Djojosugito, Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia, 40161Follow
Arfianti Arfianti, Medical Biology Department, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia, 28133
Rudi , Wisaksana, Research Centre for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia, 40161
Agnes Rengga Indrati, Clinical Pathology Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia, 40161

Abstract

Although primary integrase strand transfer inhibitor resistance mutations are currently uncommon, the increasing use of integrase strand transfer inhibitor as a key component of the first, second and third-line antiretroviral regimens suggests that the prevalence of integrase drug resistance mutations will likely increase. The rise of several polymorphic mutations and natural polymorphisms also affects the level of susceptibility of human immunodeficiency virus (HIV) type-1 to integrase strand transfer inhibitor. The considerable variability among the various subtypes of human immunodeficiency virus type-1 may contribute to differences in integrase mutations associated with integrase strand transfer inhibitors. Notably, non-B subtypes of HIV type-1 (HIV-1) are the predominant cause of human immunodeficiency virus infection worldwide. The presence of diverse integrase drug resistance mutations can have significant implications on the administration of integrase strand transfer inhibitorbased antiretroviral therapy to patients with human immunodeficiency virus infection.

Recommended Citation

Djojosugito, Fauzia Andrini; Arfianti, Arfianti; Wisaksana, Rudi ,; and Indrati, Agnes Rengga (2023) "Mutation Patterns of Integrase Gene Affect Antiretroviral Resistance in Various non-B Subtypes of Human Immunodeficiency Virus Type-1 and Their Implications for Patients’ Therapy," BioMedicine: Vol. 13 : Iss. 4 , Article 1.
DOI: 10.37796/2211-8039.1422