Estimated Levels of Glycated Albumin and C-reactive Protein/Total Albumin Ratio might Distinguish Prediabetics among the Apparently Healthy People and Predict the Vulnerability for Development of Steatohepatitis and Cardiac Risk.

Rizk S. Sarhan, Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, EgyptFollow
Raafat R Mohammed, Assistant Consultant of Medical Biochemistry, Hospital Lab, Clinical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

Abstract

Background: Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-gram oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer

Aims: The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.

Methods: IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if /dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.

Results: 253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score

Conclusion: Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR

Recommended Citation

Sarhan, Rizk S. and Mohammed, Raafat R (2025) "Estimated Levels of Glycated Albumin and C-reactive Protein/Total Albumin Ratio might Distinguish Prediabetics among the Apparently Healthy People and Predict the Vulnerability for Development of Steatohepatitis and Cardiac Risk.," BioMedicine: Vol. 15 : Iss. 1 , Article 6.
DOI: 10.37796/2211-8039.1639