Abstract
Background: The activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis.
Methods: In this study, we used a pathway-based strategy to explore possible functional pathways involved in the anticancer activity of PPARα in oral cancer cells through next-generation sequencing (NGS) and bioinformatic approaches.
Results: We found that 3919 genes were upregulated and 1060 genes were downregulated through PPARα activation. These genes were mainly involved in the proteasomal, mRNA surveillance, spliceosomal, RNA transport, and RNA degradation pathways, as indicated by GO and KEGG enrichment analysis. Importantly, a total of 13 upregulated genes in the RNA degradation pathway were identified including 3 core exosome factor genes (RRP43, RRP42,andCSL4), 2 TRAMP complex genes (TRF4andMtr4), 2 exosome cofactor genes (RRP6andMPP6), 2 CCR4-NOT complex genes (CNOT2andCNOT3), 2 Ski complex genes (SKI2andSki3), 1 decapping complex gene (EDC4), and 1 gene involved in 5’ exoribonuclease activity (XRN1).
Conclusion: Our findings suggest that the activation of PPARα to upregulate the RNA degradation pathway might provide a new strategy for oral cancer treatment.
Recommended Citation
Chang, Nai-Wen and Huang, Yi-Ping
(2019)
"The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis,"
BioMedicine: Vol. 9
:
Iss.
4
, Article 3.
DOI: 10.37796/2211-8039.1615
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This work is licensed under a Creative Commons Attribution 4.0 License.
